Duration of overall response dor
WebDuration of overall response • The duration of overall response is measured from the time measurement criteria are met for CR or PR (whichever status is recorded first) until … WebMedian Duration of Response (DOR) Among the patients who responded in DESTINY-Breast01 (n=111/184), With ~15 months mDOR, ENHERTU monotherapy extended …
Duration of overall response dor
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WebSep 17, 2024 · After a median follow-up of 5.7 months, the median duration of response (DoR) of Enhertu was 8.1 months (95% CI 4.1-NE). The median progression-free survival (PFS) was 5.5 months (95% CI 4.2-7.3). An exploratory endpoint of confirmed disease control rate (DCR) of 81% (95% CI; 70.6-89.0) was seen. Web• Primary: Best overall response rate (ORR) (complete response [CR] + partial response [PR]) a • Key secondary: Duration of response (DOR), progression-free survival (PFS), …
WebJun 2, 2024 · Overall survival (OS) and duration of response were secondary end points. RESULTS. We enrolled 101 treatment-naive and 449 previously treated patients. Median follow-up was 60.6 months (range, … WebDuration of response (DOR) and time to response (TTR) are typically evaluated as secondary endpoints in early-stage clinical studies in oncology when efficacy is assessed …
WebNumber of patients with response DOR time (min., max.), months DOR–CR time, KM median (95% CI), months: NE (NE to NE) Type of Events (Resulting in End of … WebNov 3, 2024 · • Leptomeningeal metastasis (LM) patients: response rate, disease control rate, duration of response of LM based on investigator’s assessment . ... • BM cohort: overall DCR, DOR, PFS, OS, safety and PROs • LM cohort: To evaluate DCR, DOR, PFS of intracranial disease and ORR, DCR, DOR, PFS ...
WebDoes ‘prior patient status’ refer to the target lesion assessment or the overall response. Prior status refers to the overall response, not each lesion alone. In case there is only 1 target lesion, with no non-target lesions, if the target lesion disappears and then re-appears, this would be considered to be PD, providing that if the lesion ...
WebDownload scientific diagram Flow diagram of study cohort selection steps. AR, androgen receptor; CAB, combined androgen blockade, bicalutamide and leuprorelin; CBR, clinical benefit rate; CR ... the grey stripe tolerance isWebMay 3, 2024 · When both OS and PFS differed, the ranges of true-positive or power rates were 79.2% to 98.7% for DOR, 56.3% to 93.2% for PFS, and 67.0% to 96.0% for ORR. … the greys villain earthWebDurable clinical benefit was defined as complete response (CR), partial response (PR) or stable disease (SD) as best overall response that persisted for a minimum of 24 weeks. The cut-off... the bamboo texts of guodianWebFor the end points of overall survival, progression-free survival, and objective response rate, nivolumab was either inferior or neutral to bevacizumab. The only signal potentially favoring nivolumab was from the duration of response (DOR), 1 as underscored in the accompanying Editorial. 2 The reported median DORs were 11.1 and 5.3 months for ... the bamboo terraceWebThe major efficacy outcome measures were overall response rate (ORR) and duration of response (DoR), as determined by blinded independent central review according to RECIST 1.1. the bamboo towelWebAfter the first year, overall response was assessed every 16 weeks (Cycles 17, 21, 25, etc). Responses from baseline had to be demonstrated at 2 consecutive assessments for patient to be considered a responder. 3 Median dose intensity was >95% for both treatment arms. 3 CR=complete response; PR=partial response the bamboo steamerWebMay 2, 2024 · Approval was based on overall response rate (ORR), complete response (CR) rate, and duration of response (DOR) in 100 adult patients with RRMM treated … the bamboo stylus