Lymphostatin
WebLymphostatin (LifA) is a 366 kDa protein expressed by attaching & effacing Escherichia coli. It plays an important role in intestinal colonisation and inhibits the mitogen- and antigen stimulated proliferation of lymphocytes and the synthesis of proinflammatory cytokines. LifA exhibits N-terminal homology with the glycosyltransferase domain of ... WebPreviously, we have identified a large gene (lifA, for lymphocyte inhibitory factor A) in enteropathogenic Escherichia coli (EPEC) encoding a protein termed lymphostatin that suppresses cytokine expression in vitro. This protein also functions as an adhesion factor for enterohemorrhagic E. coli (EHE …
Lymphostatin
Did you know?
WebTY - JOUR. T1 - Mode of action of lymphostatin, a multitalented inhibitor of lymphocyte function from attaching & effacing Escherichia coli. AU - Cassady-Cain, R. L. Web13 aug. 2024 · Europe PMC is an archive of life sciences journal literature.
Web11 mar. 2016 · Attaching and effacing Escherichia coli cause diarrhea and typically produce lymphostatin (LifA), an inhibitor of mitogen-activated proliferation of lymphocytes and … Web15 sept. 2024 · The third cluster, PA O-122, contains a gene (lifA/efa-1) that codes for lymphostatin, a molecule that inhibits lymphocyte proliferation and proinflammatory cytokine production . The association of EPEC with diarrhea and poor outcomes is stronger for typical EPEC than for atypical EPEC [ 1 , 2 ], with enhanced virulence modulated for …
WebResults: Lymphostatin is an effector protein encoded by lifA/efa-1 (lymphocyte inhibitory factor A/ EHEC factor for adherence). lifA/efa-1 and homologous genes have been … WebAttaching & effacing Escherichia coli cause diarrhoea and typically produce lymphostatin (LifA), an inhibitor of mitogen-activated proliferation of lymphocytes and pro-inflammatory …
WebRecombinant Lymphostatin Expression and Purification— Recombinant His-tagged lymphostatin (rLifA) was overex-pressed in E.cloni cells cultured in lysogeny broth at 37 °C, 250 rpm shaking to A 600 nm 0.8. Expression of the protein was induced by the addition of L-rhamnose to 0.2% (w/v) and cul-tured for a further3hat30°C.Cells were pelleted ...
Web1 feb. 2014 · The first genome sequenced from an obligate marine actinobacterium was that of Salinispora tropica which makes salinosporamides, sporolides and lymphostatin. Genome sequencing revealed that 10 % of the genome was devoted to secondary metabolism . At least 19 biosynthetic loci were detected that produced siderophores, … industry webexWeb5 mai 2010 · Lymphostatin/EHEC factor for adherence-1 is a novel large toxin represented in various Gram negative bacteria, highly associated with the development of infectious … industry website templates free downloadWeb1 aug. 2024 · Lymphostatin also shares a putative cysteine protease motif with LCTs. This motif is characterised by the presence of a catalytic triad that is widely conserved in the … login bwclearningcenter.comWebLymphostatin/EHEC factor for adherence-1 is a novel large toxin represented in various Gram negative bacteria, highly associated with the development of infectious diarrhea … login business taxWeb19 ian. 2016 · Attaching and effacing Escherichia coli cause diarrhea and typically produce lymphostatin (LifA), an inhibitor of mitogen-activated proliferation of lymphocytes and … login butler.pa.usWebInhibition of antigen-specific and non-specific stimulation of bovine T and B cells by lymphostatin from attaching and effacing Escherichia coli. Robin Cassady-Cain, Elizabeth Blackburn, Charlotte Bell, Elizaveta Elshina, Jayne Hope, Mark Stevens. Royal (Dick) School of Veterinary Studies; login-bxlWeb1 aug. 2010 · Lymphostatin activity could not be reliably demonstrated in lysates of EHEC O26 : H–; however, deletion of the glycosyltransferase and cysteine protease motifs in Efa-1/LifA from enteropathogenic E. coli O127 : H6 abolished lymphostatin activity. Our data uncouple the role of Efa-1/LifA in calf colonization from effects on type III secretion ... log in button html